Loxitane (Loxapine Hydrochloride)

Loxitane Review

This medication is used to treat symptoms of certain types of mental conditions. It acts in the brain to block chemicals involved with nerve sensitivity and improves concentration and self control.

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Loxitane Drug Class and Mechanism

Loxitane is a tricyclic antipsychotic. Loxitane is an anti psychotic drug of intermediate-potency. Used in the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions ( e.g. hallucinations or delusions ).

Loxitane Uses

Loxapine (sold as Loxapac®, Loxitane®) is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. It is a member of the dibenzoxazepine class and as a dibenzazepine derivative, it is structurally related to clozapine (which belongs to the chemically closely akin class of dibenzodiazepines). Several researchers have argued that Loxapine may behave as an atypical antipsychotic The typical starting dosage is 10mg twice daily; usual dose range 30-50mg twice daily; maximum recommended dosage is 250mg per day

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Loxitane Side Effects

The most significant side-effects of loxapine are excessive salivation and indifference to surroundings. Loxapine, if administered to normal persons causes emotional quietening and insensitivity. In persons with psychosis, it may control aggressive behaviour and restlessness, and reduce the severity of hallucinations and delusions. Other Side effects include tardive dyskinesia, neuroleptic malignant syndrome, extrapyramidal side effects, tremor, gynecomastia and sedation.

Loxitane Pregnancy

Safe use of loxapine during pregnancy or lactation has not been established; therefore, its use in pregnancy, in nursing mothers, or in women of childbearing potential requires that the benefits of treatment be weighed against the possible risks to mother and child. No embryotoxicity or teratogenicity was observed in studies in rats, rabbits, or dogs although, with the exception of one rabbit study, the highest dose was only two times the maximum recommended human dose and in some studies it was below this dose. Perinatal studies have shown renal papillary abnormalities in offspring of rats treated from mid-pregnancy with doses of 0.6 and 1.8 mg/kg, doses which approximate the usual human dose but which are considerably below the maximum recommended human dose.

Loxitane Overdose

Symptoms of overdose may include severe dizziness; muscle trembling, jerking, stiffness, or severe uncontrolled movements; unusual tiredness or severe weakness; distressed breathing; and loss of consciousness.

Loxitane More Information

Do not share this medicine with others for whom it was not prescribed. Do not use this medicine for other health conditions.